Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Hematological Studies on Black Cumin Oil from the Seeds of Nigella sativa L.
Shigeki ENOMOTORyoya ASANOYoshihiro IWAHORITakao NARUIYoshihito OKADAAbdel Nasser B. SINGABToru OKUYAMA
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2001 Volume 24 Issue 3 Pages 307-310


The methanol soluble portion of black cumin oil, which is prepared by compression of seeds of Nigella sativa L., showed inhibitory effects on arachidonic acid (AA)-induced platelet aggregation and blood coagulation. By bioactive assay of AA-induced platelet aggregation, the methanol soluble part was purified to isolate a new compound 2-(2-methoxypropyl)-5-methyl-1,4-benzenediol (1) and two known compounds, thymol (2), carvacrol (3), having very strong inhibitory activity. Further, we then examined the isolated compounds (1—3) and eight related compounds by the screening test for AA-induced platelet aggregation. Compounds possessing aromatic hydroxyl and acetoxyl group had more potent activity than aspirin, which is well known as a remedy for thrombosis.

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© 2001 The Pharmaceutical Society of Japan
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