Antidiabetic Activity of the Rhizoma of Anemarrhena asphodeloides and Active Components, Mangiferin and Its Glucoside

Toshihiro MIURA; Hiroyuki ICHIKI; Naoki IWAMOTO; Motoshi KATO; Masayoshi KUBO; Hiroshi SASAKI; Minoru OKADA; Torao ISHIDA; Yutaka SEINO; Keiichiro TANIGAWA

doi:10.1248/bpb.24.1009

Regular Articles

Antidiabetic Activity of the Rhizoma of Anemarrhena asphodeloides and Active Components, Mangiferin and Its Glucoside

Toshihiro MIURA, Hiroyuki ICHIKI, Naoki IWAMOTO, Motoshi KATO, Masayoshi KUBO, Hiroshi SASAKI, Minoru OKADA, Torao ISHIDA, Yutaka SEINO, Keiichiro TANIGAWA

Author information

Toshihiro MIURA
Department of Clinical Nutrition, Suzuka University of Medical Science
Hiroyuki ICHIKI
Tsumura Central Research Laboratories, Tsumura and Co.
Naoki IWAMOTO
Department of Clinical Nutrition, Suzuka University of Medical Science
Motoshi KATO
Department of Clinical Nutrition, Suzuka University of Medical Science
Masayoshi KUBO
Tsumura Central Research Laboratories, Tsumura and Co.
Hiroshi SASAKI
Tsumura Central Research Laboratories, Tsumura and Co.
Minoru OKADA
Tsumura Central Research Laboratories, Tsumura and Co.
Torao ISHIDA
Hi-tech Research Center, Suzuka University of Medical Science
Yutaka SEINO
Department of Metabolism and Clinical Nutrition, Kyoto University School of Medicine
Keiichiro TANIGAWA
Department of Clinical Nutrition, Suzuka University of Medical Science

Keywords: Anemarrhena asphodeloides, mangiferin, antidiabetic activity, KK-Ay mouse

JOURNAL FREE ACCESS

2001 Volume 24 Issue 9 Pages 1009-1011

DOI https://doi.org/10.1248/bpb.24.1009

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Abstract

The antidiabetic activity of the rhizoma of Anemarrhena asphodeloides was investigated in KK-Ay mice, an animal model of genetic type 2 diabetes. The water extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 570±29 to 401±59 mg/dl 7 h after oral administration (p<0.05) and also tended to reduce serum insulin levels in KK-Ay mice. AA-treated KK-Ay mice had significantly reduced blood glucose levels in an insulin tolerance test. Based on these results, the antidiabetic mechanism of AA may be due to decreased insulin resistance. In addition, the active components of AA were confirmed to be mangiferin and its glucoside.

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