2001 Volume 24 Issue 9 Pages 995-997
We have reported that acute restraint stress inhibits small intestinal motility in rats. In order to clarify this inhibitory mechanism, we examined the effects of α- and β-adrenergic antagonists on the inhibition of small intestinal motility induced by restraint stress. This inhibition underwent recovery by propranolol (β1/β2-antagonist) or SR59230A (β3-antagonist), but not by atenolol (β1-antagonist), ICI-118,551 (β2-antagonist), prazosin (α1-antagonist) or yohimbine (α2-antagonist). These results suggest that β3-adrenoceptors play an important role in the inhibition of small intestinal motility caused by restraint stress.