Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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β3-Adrenoceptor Is Involved in the Inhibition of Small Intestinal Motility Due to Restraint Stress in Rats
Fumitake TSUKADAMika SUGAWARAKuniko SAWAMURAYukie OHUCHIHiroyuki KOHNOYasuhito OHKUBO
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2001 Volume 24 Issue 9 Pages 995-997

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Abstract

We have reported that acute restraint stress inhibits small intestinal motility in rats. In order to clarify this inhibitory mechanism, we examined the effects of α- and β-adrenergic antagonists on the inhibition of small intestinal motility induced by restraint stress. This inhibition underwent recovery by propranolol (β12-antagonist) or SR59230A (β3-antagonist), but not by atenolol (β1-antagonist), ICI-118,551 (β2-antagonist), prazosin (α1-antagonist) or yohimbine (α2-antagonist). These results suggest that β3-adrenoceptors play an important role in the inhibition of small intestinal motility caused by restraint stress.

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© 2001 The Pharmaceutical Society of Japan
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