Estrogenic Activities of Chemicals in Diesel Exhaust Particles

Yoki Mori; Shinji Taneda; Hideyuki Hayashi; Akiyo Sakushima; Kazuyuki Kamata; Akira K. Suzuki; Shin Yoshino; Masakatsu Sakata; Masaru Sagai; Koh-ichi Seki

doi:10.1248/bpb.25.145

Communication to the Editor

Estrogenic Activities of Chemicals in Diesel Exhaust Particles

Yoki Mori, Shinji Taneda, Hideyuki Hayashi, Akiyo Sakushima, Kazuyuki Kamata, Akira K. Suzuki, Shin Yoshino, Masakatsu Sakata, Masaru Sagai, Koh-ichi Seki

Author information

Keywords: diesel exhaust particle, estrogenic activity, 4,6-dimethyldibenzothiophene, endocrine disruptor

JOURNAL FREE ACCESS

2002 Volume 25 Issue 1 Pages 145-146

DOI https://doi.org/10.1248/bpb.25.145

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Abstract

In a previous study, we focused on estrogenic activity of the hexane extract of diesel exhaust particles (DEP). The extract of hexane was first fractionated to acidic, phenolic and neutral portions according to their chemical properties, of which the neutral fraction was fractionated by column chromatography on silica gel. The chemical structures of compounds in these fractions were then analyzed. It was found that the neutral fraction of the hexane extract of DEP contains dibenzothiophene derivatives, one of which, 4, 6-dimethyldibenzothiophene, possesses estrogenic activity.

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