Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
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Synthesis, Analgesic, Anti-inflammatory and Antibacterial Activities of Some Novel 2-Phenyl-3-substituted Quinazolin-4(3H) Ones
Veerachamy AlagarsamyViswas Raja SalomonGnanavel VanikavithaVeeran PaluchamyMuniyandi Ravi ChandranAugustin Arnald SujinArunachalam ThangathiruppathySivaperuman AmuthalakshmiRajappan Revathi
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Volume 25 (2002) Issue 11 Pages 1432-1435

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A series of novel 2-phenyl-3-substituted quinazolin-4(3H)-ones have been synthesized by treating methyl-N-(2-phenyl quinazolin-3-yl-4(3H)-one) dithiocarbamate with different amines, the starting material dithiocarbamate was synthesized from anthranilic acid. The title compounds were investigated for analgesic, anti-inflammatory and antibacterial activities. All the test compounds exhibited significant activity, the compounds A1, A2 and A3 shown more potent analgesic activity, and the compound A3 shown more potent anti-inflammatory activity than the reference standard diclofenac sodium.

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© 2002 The Pharmaceutical Society of Japan
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