Abstract
In the present study, a series of 2-(3′-substituted-2′-hydroxypropylamino)pyridines were synthesized and characterized by IR, 1H-NMR and elemental analysis. The compounds were investigated for anticonvulsant (150, 300 mg/kg) and cardiac activity. 2-(3′-Diethylamino-2′-hydroxypropylamino)pyridine 3 was found to exhibit the highest anticonvulsant activity. 2-(3′-Dimethylamino-2′-hydroxypropylamino)pyridine 2 and 2-[3′-(4″-nitrophenyl-amino)-2′-hydroxypropylamino]pyridine 6 were found to exhibit negative ionotropic activity. 2-(3′-Dimethylamino-2′-hydroxypropylamino)pyridine 2, 2-[3′-(4″-nitrophenylamino)-2′-hydroxypropylamino]pyridine 6 and 2-(3′-piperidino-2′-hydroxypropylamino)pyridine 8 were found to antagonize exhibit β-adrenergic activity.
