Studies on Cancer Chemoprevention by Traditional Folk Medicines XXIV.—Inhibitory Effect of a Coumarin Derivative, 7-Isopentenyloxycoumarin, against Tumor-Promotion

Masaki Baba; Yongri Jin; Atsuo Mizuno; Hisaya Suzuki; Yoshihito Okada; Nobuo Takasuka; Harukuni Tokuda; Hoyoku Nishino; Toru Okuyama

doi:10.1248/bpb.25.244

Notes

Studies on Cancer Chemoprevention by Traditional Folk Medicines XXIV.—Inhibitory Effect of a Coumarin Derivative, 7-Isopentenyloxycoumarin, against Tumor-Promotion

Masaki Baba, Yongri Jin, Atsuo Mizuno, Hisaya Suzuki, Yoshihito Okada, Nobuo Takasuka, Harukuni Tokuda, Hoyoku Nishino, Toru Okuyama

Author information

Masaki Baba
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University
Yongri Jin
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University
Atsuo Mizuno
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University
Hisaya Suzuki
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University
Yoshihito Okada
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University
Nobuo Takasuka
Experimental Pathology and Chemotherapy Division, National Cancer Center Reseach Institute
Harukuni Tokuda
Department of Biochemistry, Kyoto Prefectural University of Medicine
Hoyoku Nishino
Department of Biochemistry, Kyoto Prefectural University of Medicine
Toru Okuyama
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

Keywords: Heracleum lanatum, anti-tumor promoting activity, ornithine decarboxylase (ODC), 7-isopentenyloxycoumarin

JOURNAL FREE ACCESS

2002 Volume 25 Issue 2 Pages 244-246

DOI https://doi.org/10.1248/bpb.25.244

Details

Abstract

7-Isopentenyloxycoumarin (1) was isolated from Heracleum lanatum Michx. (Umbelliferae). Compound 1 inhibited phospholipid metabolism and Epstein–Barr virus activation caused by a potent tumor promoter. In an in vivo experiment, topical application of 1 suppressed skin-tumor-formation induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in 7,12-dimethylbenz[a]anthracene (DMBA) initiated mice. And it also suppressed ornithine decarboxylase activity stimulated by TPA on mouse skin. These results indicated that 7-isopentenyloxycoumarin is one of the effective compounds from natural resources for treating skin tumor formation.

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