Biological and Pharmaceutical Bulletin
Notes
Antiallergic Effect of Flavonoid Glycosides Obtained from Mentha piperita L.
Toshio InoueYukio SugimotoHideki MasudaChiaki Kamei
Author information
JOURNALS FREE ACCESS

Volume 25 (2002) Issue 2 Pages 256-259

Details
Download PDF (79K) Contact us
Abstract

Six flavonoid glycosides, eriocitrin (1), narirutin (2), hesperidin (3), luteolin-7-O-rutinoside (4), isorhoifolin (5), diosmin (6), rosmarinic acid (7) and 5,7-dihydroxycromone-7-O-rutinoside (8), were isolated from the aerial part of Mentha piperita L. Among these compounds, compound 4 showed a potent inhibitory effect on histamine release induced by compound 48/80 and antigen-antibody reaction. This compound was more effective than luteolin and luteolin-7-O-glucoside in inhibiting histamine release from rat peritoneal mast cells. Compound 4 also caused a dose-related inhibition of the antigen-induced nasal response and significant effects were observed at doses of 100 and 300 mg/kg. These results indicate that compound 4 may be clinically useful in alleviating the nasal symptoms of allergic rhinitis.

Information related to the author
© 2002 The Pharmaceutical Society of Japan
Previous article Next article

Recently visited articles
feedback
Top