Neuritogenesis of Herbal (+)- and (−)-Syringaresinols Separated by Chiral HPLC in PC12h and Neuro2a Cells

Kenzo Chiba; Matsumi Yamazaki; Emiko Umegaki; Ming Run Li; Zhen Wen Xu; Sumio Terada; Michihiro Taka; Noriyuki Naoi; Tetsuro Mohri

doi:10.1248/bpb.25.791

Notes

Neuritogenesis of Herbal (+)- and (−)-Syringaresinols Separated by Chiral HPLC in PC12h and Neuro2a Cells

Kenzo Chiba, Matsumi Yamazaki, Emiko Umegaki, Ming Run Li, Zhen Wen Xu, Sumio Terada, Michihiro Taka, Noriyuki Naoi, Tetsuro Mohri

Author information

Keywords: syringaresinol, optical isomer, neuritogenesis, PC12h cell, Epimedium koreanum

JOURNAL FREE ACCESS

2002 Volume 25 Issue 6 Pages 791-793

DOI https://doi.org/10.1248/bpb.25.791

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Abstract

Syringaresinol isolated from Epimedium koreanum NAKAI and Magnolia officinalis REHD. et WILS. was subjected to optical resolution by chiral HPLC to give (+)- and (−)-enantiomers. The two syringaresinol enantiomers, as well as a mixture of their glucosides, showed dose-dependent neuritogenesis in a concentration range from 0.24 to 24 μM in PC12h cells.

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