Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Anti-allergic Effects of Cnidii Monnieri Fructus (Dried Fruits of Cnidium monnieri) and Its Major Component, Osthol
Hideaki MatsudaNorimichi TomohiroYasuko IdoMichinori Kubo
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2002 Volume 25 Issue 6 Pages 809-812

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Abstract

Anti-allergic effects (types I and IV) of the 70% ethanol extract (CM-ext) obtained from Cnidii Monnieri Fructus (dried fruits of Cnidium monnieri) were investigated on 48 h homologous passive cutaneous anaphylaxis (PCA), 2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis and picryl chloride (PC)-induced contact dermatitis in experimental animals. CM-ext showed inhibitory effects on these allergic models. Osthol isolated from CM-ext also had the inhibitory effects. These results suggested that Cnidii Monnieri Fructus might be useful as an agent for allergic diseases and that its anti-allergic effect was partially attributable to a coumarin derivative, osthol.

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© 2002 The Pharmaceutical Society of Japan
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