Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Notes
Effect of Berberine on Bone Mineral Density in SAMP6 as a Senile Osteoporosis Model
Huiying LiTatsuro MiyaharaYasuhiro TezukaQuan Le TranHikaru SetoShigetoshi Kadota
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2003 Volume 26 Issue 1 Pages 110-111

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Abstract

The effects of berberine in senescence accelerated mice P6 (SAMP6) were investigated to learn whether the alkaloid affects bone mineral density (BMD). Oral administration of berberine (10 mg/kg/d) to male and female mice for 22 weeks resulted in an increase in BMD in both sexes. A decreased concentration of deoxypyridinoline (Dpd) in urine was only observed in female mice. There was no effect on body or tibia weight or on the concentration of procollagen type I carboxyterminal extension peptide (PICP) in serum.

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© 2003 The Pharmaceutical Society of Japan
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