Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Trypanocidal Constituents in Plants 2.
Xanthones from the Stem Bark of Garcinia subelliptica
Fumiko AbeShinya NagafujiHikaru OkabeHiroo HigoHiroshige Akahane
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2003 Volume 26 Issue 12 Pages 1730-1733

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Abstract

The constituents of the stem bark of Garcinia subelliptica (Guttiferae) were investigated based on its trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent for Chagas' disease. As the active components, nine xanthones were isolated including two new ones, 4-hydroxybrasilixanthone B and 1,3,5,6-tetrahydroxy-4,7,8-tri(3-methyl-2-butenyl)xanthone. Their structures were determined by spectroscopic analysis. Trypanocidal activity against trypomastigotes, an infectious form of T. cruzi, was also estimated as well as cytotoxic activity. Fukugetin, the major component of the bark, showed no activity.

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© 2003 The Pharmaceutical Society of Japan
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