A Synthetic Retinoid Am80 (Tamibarotene) Rescues the Memory Deficit Caused by Scopolamine in a Passive Avoidance Paradigm

Koichi Shudo; Hiroyuki Kagechika; Noriyuki Yamazaki; Masaharu Igarashi; Chiaki Tateda

doi:10.1248/bpb.27.1887

Communications to the Editor

A Synthetic Retinoid Am80 (Tamibarotene) Rescues the Memory Deficit Caused by Scopolamine in a Passive Avoidance Paradigm

Koichi Shudo, Hiroyuki Kagechika, Noriyuki Yamazaki, Masaharu Igarashi, Chiaki Tateda

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Keywords: retinoid, Alzheimer's disease, tamibarotene, dementia, RAR-ligand

JOURNAL FREE ACCESS

2004 Volume 27 Issue 11 Pages 1887-1889

DOI https://doi.org/10.1248/bpb.27.1887

[Correction] Biol. Pharm. Bull. Vol.28 (2005) No.12 pp.2346-2346

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Abstract

Memory deficit in rats treated with scopolamine was rescued by several synthetic retinoids, RAR-ligands (Am80, Am555S, Tp80) and an RXR-ligand (HX630). These results may have implications for the treatment of Alzheimer's disease, age-related dementia, Parkinson's disease, and other neurological disorders.

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