Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
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Corosolic Acid Induces GLUT4 Translocation in Genetically Type 2 Diabetic Mice
Toshihiro MiuraYasushi ItohTetsuo KanekoNaoya UedaTorao IshidaMitsuo FukushimaFutoshi MatsuyamaYutaka Seino
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Volume 27 (2004) Issue 7 Pages 1103-1105

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The effect of corosolic acid (CA) on blood glucose was studied in KK-Ay mice, an animal model of type 2 diabetes. CA (10 mg/kg) reduced the blood glucose (p<0.05) of KK-Ay mice 4 h after single oral administration when compared with the control group. However, CA did not change the plasma insulin. The muscle facilitative glucose transporter isoform 4 (GLUT4) translocation from low-density microsomal membrane to plasma membrane was significantly increased in the orally CA-treated mice when compared with that of the controls (p<0.05). These results suggest that the hypoglycemic effect of CA is derived, at least in part, from an increase in GLUT4 translocation in muscle. Therefore, it may be that CA has beneficial effects on hyperglycemia in type 2 diabetes.

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© 2004 The Pharmaceutical Society of Japan
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