Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
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Antiproliferative Constituents from Umbelliferae Plants VII. Active Triterpenes and Rosmarinic Acid from Centella asiatica
Miyako YoshidaMasahiro FuchigamiTsuneatsu NagaoHikaru OkabeKazuhisa MatsunagaJiro TakataYoshiharu KarubeRyota TsuchihashiJunei KinjoKunihide MihashiToshihiro Fujioka
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2005 Volume 28 Issue 1 Pages 173-175

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Abstract

The antiproliferative constituents in the MeOH extract from the aerial parts of Centella asiatica were investigated. Activity-guided fractionation of MeOH extract resulted in the isolation of ursolic acid lactone, ursolic acid, pomolic acid, 2α,3α-dihydroxyurs-12-en-28-oic acid, 3-epimaslinic acid, asiatic acid, corosolic acid, and rosmarinic acid. Antiproliferative activity of the isolated compounds against human gastric adenocarcinoma (MK-1), human uterine carcinoma (HeLa), and murine melanoma (B16F10) cells was estimated.

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© 2005 The Pharmaceutical Society of Japan
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