Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Protective Effect of Ginsenoside-Re against Cerebral Ischemia/Reperfusion Damage in Rats
Xiao-Mian ZhouYing-Lin CaoDe-Qiang Dou
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2006 Volume 29 Issue 12 Pages 2502-2505

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Abstract

To investigate the protective effect of ginsenoside Re (Re) against cerebral ischemia–reperfusion injury, adult male Wistar rats weighing 250—300 g were subjected to either sham surgery or middle cerebral artery occlusion (MCAO) for 2 h of brain ischemia and 2 h reperfusion. A fluorescence polarization assay was carried out for membrane fluidity of brain mitochondria. Lipid peroxidation [malondiadehyde (MDA) formation], superoxide dismutase (SOD) and glutathion peroxidase (GSH-Px) of rat brain were estimated by fluorometric methods. It was observed that Re (5, 10, 20 mg kg−1 p.o. pretreatment for 7 d, once a day) significantly improved the fluidity of mitochondrial membranes as demonstrated by a reduction of average microviscosity, ameliorated lipid peroxidation by raising the activities of SOD and GSH-Px, and reduced the content of MDA in rat brain. This study demonstrated a direct protective effect of Re against cerebral ischemia–reperfusion injury.

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© 2006 The Pharmaceutical Society of Japan
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