Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Antioxidant Effects of Quinoline Alkaloids and 2,4-Di-tert-butylphenol Isolated from Scolopendra subspinipes
Mi-Ae YoonTae-Sook JeongDoo-Sang ParkMing-Zhe XuHyun-Woo OhKyoung-Bin SongWoo Song LeeHo-Yong Park
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2006 Volume 29 Issue 4 Pages 735-739

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Abstract

The oxidized low-density lipoprotein (ox-LDL) plays a critical role at the early stages of atherosclerosis. Thus, the prevention of LDL-oxidation by antioxidants may arrest the progression of atherosclerosis. Two quinoline alkaloids, 3,8-dihydroxyquinoline (1) and 2,8-dihydroxy-3,4-dimethoxyquinoline (3), and 2,4-di-tert-butylphenol (2) were isolated from the dried body of Scolopendra subspinipes. Compounds 1—3 exhibited antioxidant activities on copper-mediated (1: IC50=2.6 μM, 2: IC50=8.2 μM, 3: IC50=63.0 μM), AAPH-mediated oxidation (1: IC50=3.9 μM, 2: IC50=9.9 μM, 3: IC50=71.8 μM), and SIN-1-mediated oxidation (1: 70%, 2: 52%, 3: 29% at 5.0 μM) in the TBARS assay. The antioxidant activities of compounds 1—3 were tested with respect to other parameters, such as the lag time of conjugated diene fromation, relative electrophoretic mobility (REM) of ox-LDL, and apoB-100 fragmentation on copper-mediated LDL-oxidation. In addition, compounds 1—3 showed 1,1-diphenyl-2-picrylhydrasyl (DPPH) radical scavenging activity and compound 1 also exhibited metal chelating activity.

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© 2006 The Pharmaceutical Society of Japan
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