Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Inhibition of Nuclear Factor-κB Activation by 2′,8″-Biapigenin
Eun-Rhan WooYuba Raj PokharelJin Won YangSong Yi LeeKeon Wook Kang
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2006 Volume 29 Issue 5 Pages 976-980


Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) play a key role in the inflammatory processes. Improper overproduction of NO and prostaglandins by both enzymes are also believed to be involved in the pathogenesis of certain human cancers. Crude extracts of Selaginella tamariscina are used as an oriental medicine, which has been reported to inhibit the production of proinflammatory cytokines and cause cell cycle arrest. We isolated 2′,8″-biapigenin from S. tamariscina and investigated whether it modulates iNOS and COX-2 expressions in Raw264.7 macrophages stimulated with lipopolysaccharide (LPS). We found that 2′,8″-biapigenin blocked the transactivations of iNOS and COX-2 genes via the inactivation of nuclear factor-κB by preventing the nuclear translocation of p65. Hence, it may be possible to develop S. tamariscina extracts or 2′,8″-biapigenin as a useful agent for cancer chemoprevention or for the treatment of inflammatory diseases.

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© 2006 The Pharmaceutical Society of Japan
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