Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Differential Antiviral Activity of Benzastatin C and Its Dechlorinated Derivative from Streptomyces nitrosporeus
Jong-Gyo LeeIck-Dong YooWon-Gon Kim
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2007 Volume 30 Issue 4 Pages 795-797

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Abstract

Benzastatin C, a 3-chloro-tetrahydroquinolone alkaloid from Streptomyces nitrosporeus, showed antiviral activity in a dose-dependant manner with EC50 values of 1.92, 0.53, and 1.99 μg/ml against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and vesicular stomatitis virus (VSV), respectively. In contrast, benzastatin D, the corresponding dechlorinated derivative, did not exhibit any antiviral activity. These results indicate that the antiviral activity of benzastatin C is mediated, in part, due to the chlorine moiety in its molecular structure.

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© 2007 The Pharmaceutical Society of Japan
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