Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Antinociceptive Effect of the Monoterpene R-(+)-Limonene in Mice
Jeferson Falcão do AmaralMaria Izabel Gomes SilvaManuel Rufino Aquino de Aquino NetoPaulo Florentino Teixeira NetoBrinell Arcanjo MouraCarla Thiciane Vasconcelos de MeloFernando Luiz Oliveira de AraújoDamião Pergentino de SousaPatrícia Freire de VasconcelosSilvânia Maria Mendes de VasconcelosFrancisca Cléa Florenço de Sousa
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2007 Volume 30 Issue 7 Pages 1217-1220


In the present study were studied the antinociceptives properties of monoterpene R-(+)-limonene (LM) in chemical and thermal models of nociception in mice. The R-(+)-limonene was administered, intraperitoneally (i.p.), at doses of 25 and 50 mg/kg. The results showed significant inhibition produced on chemical nociception induced by intraperitoneal acetic-acid and in the second phase of subplantar formalin test, but did not manifest a significant effect in hot-plate test. The R-(+)-limonene-induced antinociception in second phase of formalin test was insensitive to naloxone (1 mg/kg, s.c.). It was also demonstrated that R-(+)-limonene (25, 50 mg/kg) neither significantly enhanced the pentobarbital-sleeping time nor impaired the motor performance in rota-rod test, indicating that the observed antinociception is unlikely to be due to sedation or motor abnormality. In conclusion it may be suggested that the R-(+)-limonene presented antinociceptive activity and that, probably, this action can be related with peripheral analgesia, but, not with the stimulation of opioids receptors.

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© 2007 The Pharmaceutical Society of Japan
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