Abstract
Correction:
In the manuscript described above, we have described the effect of plagiochin E alone and in combination with fluconazole on the ergosterol biosynthesis of Candida albicans. Now we found a fatal error occurred during the sterol content calculation according to Fig. 3A. Based on this wrong datum, the calculation of relative sterol composition of C. albicans CA10 has provided wrong results in Table 2. According to the correct data, for plagiochin E on the resistant strain CA10, ergosterol percentage was reduced, but, lanosterol and 14α-methylfecosterol were accumulated. So when FLC-resistant strain was treated by PLE, the accumulation of 14α-methylated sterols (lanosterol and 14α-methylfecosterol) and the down regulation of ERG11 may indicate the other mechanism for resistance reverse.
We therefore deleted this publication of Biol. Pharm. Bull.
Ling Mei SUN
School of Pharmaceutical Sciences, Shandong University, China
February 3, 2009
