Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Function of K+–Cl− Cotransporters in the Acid Secretory Mechanism of Gastric Parietal Cells
Takuto Fujii, Kyosuke Fujita, Noriaki Takeguchi, Hideki Sakai
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Keywords: gastric acid secretion, K+–Cl− cotransporter, H+, K+-ATPase, Na+, K+-ATPase, gastric parietal cell
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2011 Volume 34 Issue 6 Pages 810-812

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Abstract
Gastric proton pump (H+, K+-ATPase) secretes H+ of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl−- and K+-transporting proteins are required. Recent our studies have demonstrated that K+–Cl− cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. KCC3a is associated with Na+, K+-ATPase in the basolateral membrane, and KCC4 is associated with H+, K+-ATPase in the apical canalicular membrane. This paper summarizes the functional association between KCCs and P-type ATPases and the contribution of these complexes to acid secretion in gastric parietal cells.
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© 2011 The Pharmaceutical Society of Japan
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