Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Natural Vanadium-Containing Jeju Groundwater Inhibits Immunoglobulin E-Mediated Anaphylactic Reaction and Suppresses Eicosanoid Generation and Degranulation in Bone Marrow Derived-Mast Cells
Xian LiYue LuJu Hye YangYe JinSeung-Lark HwangHyeun Wook Chang
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2012 Volume 35 Issue 2 Pages 216-222

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Abstract

The high-affinity receptor for immunoglobulin E (IgE) (FcεRI)-mediated activation of mast cells plays an important role in various allergic diseases. To assess the anti-allergic activity of natural vanadium-containing Jeju groundwater (JW), an in vivo passive cutaneous anaphylaxis (PCA) animal model and in vitro mouse bone marrow-derived mast cells (BMMCs) was used. JW inhibited cyclooxygenase-2 (COX-2)-dependent prostaglandin D2 (PGD2) generation in a dose-dependent manner, with a concomitant reduction of COX-2 protein expression in IgE-induced BMMCs. In addition, JW inhibited 5-lipoxygenase (5-LOX)-dependent generation of leukotriene C4 (LTC4) as well as degranulation in a dose-dependent manner. These results demonstrate that JW has dual COX-2/5-LOX inhibitory activity. In addition, vanadium pentoxide (V2O5), which is the major vanadium component of JW, also inhibited PGD2 and LTC4 generation as well as degranulation in IgE-induced BMMCs. Furthermore, oral administration of JW dose-dependently inhibited mast cell-dependent passive anaphylactic reaction in IgE-sensitized mice. Taken together, these results suggest that JW may be useful in regulating mast cell-mediated allergic response through the suppression of eicosanoid generation and degranulation in mast cells.

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© 2012 The Pharmaceutical Society of Japan
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