Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Current Topics
Effects of Ashwagandha (Roots of Withania somnifera) on Neurodegenerative Diseases
Tomoharu KuboyamaChihiro TohdaKatsuko Komatsu
Author information
JOURNALS FREE ACCESS FULL-TEXT HTML

2014 Volume 37 Issue 6 Pages 892-897

Details
Abstract

Neurodegenerative diseases commonly induce irreversible destruction of central nervous system (CNS) neuronal networks, resulting in permanent functional impairments. Effective medications against neurodegenerative diseases are currently lacking. Ashwagandha (roots of Withania somnifera Dunal) is used in traditional Indian medicine (Ayurveda) for general debility, consumption, nervous exhaustion, insomnia, and loss of memory. In this review, we summarize various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer’s disease and spinal cord injury.

Information related to the author
© 2014 The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top