Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
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Calix[8]arene Sulfonic Acid Catalyzed Three-Component Reaction for Convenient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones under Ultrasonic Irradiation
Lin AnLi-li HanZu-jian WangTong-hui HuangHui-dong Zhu
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Volume 39 (2016) Issue 2 Pages 267-271

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Abstract

In this work, the catalytic activity of calix[8]arene sulfonic acid was successfully investigated for the famous Biginelli reaction. Under ultrasonic irradiation, calix[8]arene sulfonic acid could efficiently catalyzed the three-component reaction of aldehydes with ethyl acetoacetate and urea or thiourea in ethanol to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones/thiones in 46–93%. The advantages of this method are the easy isolated procedure, short reaction time and low cost of the catalyst.

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© 2016 The Pharmaceutical Society of Japan
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