Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
Effects of products containing Bacillus subtilis var. natto on healthy subjects with neck and shoulder stiffness, a double-blind, placebo-controlled, randomized crossover study
Yoichi SunagawaNobuko OkamuraYusuke MiyazakiKana ShimizuMai GenpeiMasafumi FunamotoSatoshi ShimizuYasufumi KatanasakaEriko MorimotoHajime YamakageMaki KomiyamaNoriko Satoh-AsaharaHiromichi WadaMika SuzukiKoji HasegawaTatsuya Morimoto
Author information
JOURNALS FREE ACCESS Advance online publication

Article ID: b17-00780


Neck and shoulder stiffness is a typical subjective symptom in developed countries. This stiffness is caused by factors such as muscle tension and poor blood flow, leading to reduce work efficiency and diminish quality of life. NKCP®, a natto-derived dietary food supplement whose main component is bacillopeptidase F, has antithrombotic, fibrinolytic, and blood viscosity-lowering effects. Here, we investigated the effect of NKCP® on neck and shoulder stiffness in a double-blind placebo-controlled randomized crossover study.

Thirty subjects with neck and shoulder stiffness were randomly divided into 2 groups and ingested 250 mg of NKCP® or placebo daily for 4 weeks. Headache score significantly improved in the NKCP® group compared to the placebo group. Moreover, NKCP® significantly improved the score of visual analogue scale for neck and shoulder stiffness and pain, reduced muscle stiffness of the neck, and increased the skin surface temperature of neck and shoulders, compared to before ingestion. No adverse effects were observed during this study.These results suggest that NKCP® may alleviate headaches and chronic neck and shoulder stiffness and pain.

Information related to the author
© 2018 The Pharmaceutical Society of Japan