抄録
The effect of monoolein-bile salts, sodium glycocholate and sodium taurocholate, mixed micellar solutions on the intestinal absorption of heparin was investigated using the in situ closed loop of the rats. It was observed that these mixed micellar solutions extremely enhanced the absorption of heparin and that the mixed micellar solution prepared with distilled water facilitated the intestinal absorption of heparin more markedly than that prepared with pH 6.5 phosphate buffer solution. This difference between mixed micellar distilled water solution and mixed micellar buffer solution was studied by ultrafiltration, pretreatment with the micellar and mixed micellar solutions, and gut exsorption. Enhanced permeability is discussed from the standpoints of intraluminal interaction between the mixed micelles and heparin molecules, and an alternation in the permeability of the mucosal membrane.
