Biological and Pharmaceutical Bulletin
日本薬学会は,1880年に創立された,我が国では歴史ある学会の一つです.現在,約18000人の会員を擁しており,毎月3誌の学術誌を刊行しております.英文による学術誌の一つとして「Chemical and Pharmaceutical Bulletin」(Chem. Pharm. Bull.)は, 1953年にPharmaceutical Bulletinとして創刊され,その後Chem. Pharm. Bull. と名称を変え,薬学と健康科学に関する化学分野をカバーしています.二つ目として,「Biological and Pharmaceutical Bulletin」(Biol. Pharm. Bull.) があり,これは1978年に創刊されたJournal Pharmacobio-Dynamicsを起源としており,更に1953年に創刊され,2012年に内容を引き継いだJournal of Health Scienceの後継誌として,薬学と健康科学に関する生物学分野を領域としています.英文と和文両方にて構成される学術誌として,「YAKUGAKU ZASSHI」(薬学雑誌)があり,本学術誌は学会創立の翌年(1881年)に創刊され,最も長い歴史を有しています.薬学雑誌では,和文による原著論文・総説等のほか,臨床薬学領域研究については英文による投稿も受け付けています. 日本薬学会におけるこれら学術誌のスコープは,基礎研究から臨床研究に至る幅広い分野に渡りますが,いずれも薬学・健康科学をベースとしています。3誌に投稿された論文の平均審査期間は,現在,投稿された方へ最初の判定を通知するまでに約1か月ですが,更なる時間短縮を目指しています.3誌ともにJ-STAGEにて無料公開しており,研究成果を世に広める一助となることを期待しております.皆様の研究成果をChem. Pharm. Bull.やBiol. Pharm. Bull.,薬学雑誌へ積極的にご投稿下さいますよう,よろしくお願い申し上げます.

大槻 純男
収録数 10,234本
(更新日 2020/07/04)
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
2018 Journal Impact Factor (JIF)
ジャーナル 査読 フリー HTML 早期公開
Scopus Pubmed
43 巻 (2020) 7 号 p. 1061-1066
Evidence of Passive Smoking as a Risk Factor of High-Grade Squamous Intraepithelial Lesion: A Case-Control Study もっと読む

The association between risk factors and occurrence or development of cervical intraepithelial lesions, such as persistent infection with high-risk human papillomavirus (HPV), multiple sexual partners and smoking have been discussed. However, the effect of passive smoking on the disease is unclear. In this case-control study, Du et al. found that passive smoking was a significant independent risk factor on the occurrence of HSIL and showed a positive correlated dose-response relationship. HPV infection interacting with passive smoking led to an even higher disease risk. Adolescent exposure to passive smoking persistent for more than 20 years would also increase the HSIL risk.

43 巻 (2020) 7 号 p. 1104-1110
Latifolin Inhibits Oxidative Stress-Induced Senescence via Upregulation of SIRT1 in Human Dermal Fibroblasts もっと読む

Aging is the most important risk factor for various diseases such as cancer, osteoarthritis, dementia, atherosclerosis, and infection. Therefore, the researchers has attempted to find phytochemicals for ameliorating aging-related diseased. Latifolin, isolated from Dalbergia odorifera T. Chen, has been reported to exhibit anti-inflammatory and anti-carcinogenic activities. In present study, the authors investigated the anti-aging effect of latifolin in human dermal fibroblasts. Modulation of SIRT1 may be involved in latifolin protective effect against H2O2-induced oxidant injury. These results suggest that latifolin supplementation might be a possible route for improving aging and age-related diseases.

43 巻 (2020) 7 号 p. 1111-1117
Pharmacological Characterization of a Novel Mouse Model of Cholestatic Pruritus もっと読む

Patients with cholestatic liver diseases, such as primary biliary cirrhosis, usually suffer from pruritus. However, the pathogenesis of cholestatic pruritus is unclear, and there is no current effective treatment for it. In order to find a treatment for the condition, an appropriate mouse model should be developed. Andoh et al. established a surgically-induced mouse model of cholestatic pruritus and evaluated anti-pruritic effects of several drugs using this mouse model. In results, they suggested that partial obstruction of bile secretion in mice induced anti-histamine-resistant itching and that central opioid system is involved in cholestatic itching.

43 巻 (2020) 7 号 p. 1118-1122
Single Molecule Fluorescence Imaging Reveals the Stoichiometry of BKγ1 Subunit in Living HEK293 Cell Expression System もっと読む

Large conductance Ca2+-activated K+ (BKCa) channels possess significant physiological functions in various types of cells. The stoichiometry between BKa and newly identified ɤ1 subunits (BKɤ1) remains unclear. Here, the authors utilized a single molecule fluorescence imaging with a total internal reflection fluorescence (TIRF) microscope to directly count the number of GFP-tagged BKɤ1 within a single BKCa channel complex in HEK293 expression system. Counting of GFP bleaching steps revealed that a BKCa channel contains mainly four BKɤ1 per channel. These results suggest that BKɤ1 forms a BKCa channel complex with BKa in a 1:1 stoichiometry in a human cell line.

月間アクセス数ランキング 2020年06月
  • Biol. Pharm. Bull. Vol. 43 No. 4 Current Topics: Recent  Advances  in  Research  on  Particulate  Formulations  such  as  Lipoproteins,  Liposomes,  Extracellular  Vesicles,  and  iPS-Derived  Cells
  • Biol. Pharm. Bull. Vol. 43 No. 3
    Current Topics: Drug Discovery: Recent Progress and the Future
  • Biol. Pharm. Bull. Vol. 43 No. 2
    Current Topics: Challenges in the Control of Environmental Pathogenic Microbes
  • Biol. Pharm. Bull. Vol. 43 No. 1
    Current Topics: Recent Advances in Research on the Mechanisms and Regulation of Allergic Diseases