Biological and Pharmaceutical Bulletin
日本薬学会は,1880年に創立された,我が国では歴史ある学会の一つです.現在,約18000人の会員を擁しており,毎月3誌の学術誌を刊行しております.英文による学術誌の一つとして「Chemical and Pharmaceutical Bulletin」(Chem. Pharm. Bull.)は, 1953年にPharmaceutical Bulletinとして創刊され,その後Chem. Pharm. Bull. と名称を変え,薬学と健康科学に関する化学分野をカバーしています.二つ目として,「Biological and Pharmaceutical Bulletin」(Biol. Pharm. Bull.) があり,これは1978年に創刊されたJournal Pharmacobio-Dynamicsを起源としており,更に1953年に創刊され,2012年に内容を引き継いだJournal of Health Scienceの後継誌として,薬学と健康科学に関する生物学分野を領域としています.英文と和文両方にて構成される学術誌として,「YAKUGAKU ZASSHI」(薬学雑誌)があり,本学術誌は学会創立の翌年(1881年)に創刊され,最も長い歴史を有しています.薬学雑誌では,和文による原著論文・総説等のほか,臨床薬学領域研究については英文による投稿も受け付けています. 日本薬学会におけるこれら学術誌のスコープは,基礎研究から臨床研究に至る幅広い分野に渡りますが,いずれも薬学・健康科学をベースとしています。3誌に投稿された論文の平均審査期間は,現在,投稿された方へ最初の判定を通知するまでに約1か月ですが,更なる時間短縮を目指しています.3誌ともにJ-STAGEにて無料公開しており,研究成果を世に広める一助となることを期待しております.皆様の研究成果をChem. Pharm. Bull.やBiol. Pharm. Bull.,薬学雑誌へ積極的にご投稿下さいますよう,よろしくお願い申し上げます.

学術誌編集委員長
大槻 純男
熊本大学大学院生命科学研究部
もっと読む
収録数 10,290本
(更新日 2020/09/22)
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
1.863
2019 Journal Impact Factor (JIF)
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おすすめ記事
43 巻 (2020) 9 号 p. 1293-1300
Current Understanding of the Intestinal Absorption of Nucleobases and Analogs もっと読む
編集者のコメント

Knowledge of the intestinal absorption of nucleobases and analogs has accumulated, as is generally the case, mainly from studies using non-primate experimental animals. However, the recent identification of sodium-dependent nucleobase transporter 1, which plays a major role in their absorption in such animals, has led to exposing the fact that this important transporter is genetically missing in humans. To help to embark on efforts now needed to elucidate the mechanism of intestinal absorption of nucleobases and analogs in humans, which could be totally different from that in non-primate experimental animals, this article presents a comprehensive review on relevant knowledge and issues.

43 巻 (2020) 9 号 p. 1315-1323
Osthole Improves Cognitive Function of Vascular Dementia Rats: Reducing Aβ Deposition via Inhibition NLRP3 Inflammasome もっと読む
編集者のコメント

Vascular dementia (VD) is a common neurodegenerative disease, in the progress of which neuroinflammation and beta-amyloid (Aβ) deposition act as vital elements. In this study, lots of Aβ and nod-like receptor protein 3 (NLRP3) inflammasome were found in VD rats’ brains induced by bilateral common carotid artery occlusion. A traditional Chinese medicine-Shechuangzi (osthole) extracted from the fruit of Cnidium monnieri (L.) possesses multiple pharmacological characteristics. This study has been proved the effect of osthole on VD rat evidenced by improving the behavior function, inhibiting the activation of microglia and reducing NLRP3 content, as well as decreasing the Aβ formation.

43 巻 (2020) 9 号 p. 1346-1355
Synergistic Interaction of Ochratoxin A and Acrylamide Toxins in Human Kidney and Liver Cells もっと読む
編集者のコメント

The toxicity of each ochratoxin A and acrylamide is known but there is uncertainty about the cumulative toxicity of two compounds. In this research, Pyo et al. demonstrated that there is a synergistic relationship between ochratoxin A and acrylamide that raises oxidative stress, reduces antioxidant enzymes and causes apoptosis, exacerbating liver and kidney toxicity. These findings indicate that the risk could be increased further by the food-borne toxicant 's interaction with the toxicant produced during processing.

43 巻 (2020) 9 号 p. 1367-1374
Influence of Crocetin, a Natural Carotenoid Dicarboxylic Acid in Saffron, on L-Type Ca2+ Current, Intracellular Ca2+ Handling and Contraction of Isolated Rat Cardiomyocytes もっと読む
編集者のコメント

Crocetin is a major bioactive component in saffron (Crocus sativus L.) and it has favorable cardiovascular protective effects. This study investigated the regulative effects of crocetin on L-type Ca2+ current (ICa-L), contractility, and the Ca2+ transients in rat ventricular cardiomyocytes using patch-clamp technique and Ion Optix system. The results indicated that crocetin inhibited ICa-L, intracellular Ca2+ concentration and contractility of cardiomyocytes. Crocetin (600 μg/ml) reduced cell shortening and the crest value of the ephemeral Ca2+ by 28.6 ± 2.31%, 31.87 ± 2.57%, respectively. These findings reveal that crocetin could be a potential calcium blocker for the treatment of cardiovascular disease.

43 巻 (2020) 9 号 p. 1398-1406
Development of a Diagnostic Screening Strategy for Niemann–Pick Diseases Based on Simultaneous Liquid Chromatography-Tandem Mass Spectrometry Analyses of N-Palmitoyl-O-phosphocholine-serine and Sphingosylphosphorylcholine もっと読む
編集者のコメント

Niemann-Pick diseases are classified into types A/B and C and early definitive diagnosis of them is important for better prognosis of the diseases. The authors developed a novel diagnostic screening strategy for Niemann-Pick diseases using a combination of serum concentrations of N-Palmitoyl-O-phosphocholine-serine and sphingosylphosphocholine based on analyses by liquid chromatography/tandem mass spectrometry. In this study, a rapid method and a validated analysis were developed. The former was useful for screening and the latter were useful for differentiation of Niemann–Pick diseases. This strategy may be useful for screening of Niemann-Pick diseases in clinical practice.

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