Biological and Pharmaceutical Bulletin
日本薬学会は,1880年に創立された,我が国では歴史ある学会の一つです.現在,約17000人の会員を擁しており,毎月3誌の学術誌を刊行しております.英文による学術誌の一つとして「Chemical and Pharmaceutical Bulletin」(Chem. Pharm. Bull.)は, 1953年にPharmaceutical Bulletinとして創刊され,その後Chem. Pharm. Bull. と名称を変え,薬学と健康科学に関する化学分野をカバーしています.二つ目として,「Biological and Pharmaceutical Bulletin」(Biol. Pharm. Bull.) があり,これは1978年に創刊されたJournal Pharmacobio-Dynamicsを起源としており,更に1953年に創刊され,2012年に内容を引き継いだJournal of Health Scienceの後継誌として,薬学と健康科学に関する生物学分野を領域としています.英文と和文両方にて構成される学術誌として,「YAKUGAKU ZASSHI」(薬学雑誌)があり,本学術誌は学会創立の翌年(1881年)に創刊され,最も長い歴史を有しています.薬学雑誌では,和文による原著論文・総説等のほか,臨床薬学領域研究については英文による投稿も受け付けています. 日本薬学会におけるこれら学術誌のスコープは,基礎研究から臨床研究に至る幅広い分野に渡りますが,いずれも薬学・健康科学をベースとしています。3誌に投稿された論文の平均審査期間は,現在,投稿された方へ最初の判定を通知するまでに約1か月ですが,更なる時間短縮を目指しています.3誌ともにJ-STAGEにて無料公開しており,研究成果を世に広める一助となることを期待しております.皆様の研究成果をChem. Pharm. Bull.やBiol. Pharm. Bull.,薬学雑誌へ積極的にご投稿下さいますよう,よろしくお願い申し上げます.

大槻 純男
収録数 10,613本
(更新日 2021/09/18)
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
2020 Journal Impact Factor (JIF)
ジャーナル 査読 フリー HTML 早期公開
Scopus Pubmed
44 巻 (2021) 9 号 p. 1167-1173
Elucidation of the Physiological Functions of Membrane Proteins as Novel Drug Target Candidate Molecules もっと読む

Membrane proteins, such as G protein-coupled receptors (GPCRs) and ion channels play diverse physiological functions by converting extracellular stimuli into intracellular signals. Hence, membrane proteins are the major category of drugs targets. In this review, the author summarizes recent findings on the physiological functions of GPCR, which senses medium- and long-chain free fatty acids, in the regulation of systemic energy metabolism and the physiological role of ion channels, which involved in the regulation of intracellular calcium, in bone formation. The author further describes the importance of these membrane proteins in future clinical applications.

44 巻 (2021) 9 号 p. 1174-1183
Hospital Pharmacometrics for Optimal Individual Administration of Antimicrobial Agents for Anti-methicillin-resistant Staphylococcus aureus Infected Patients もっと読む

Modeling and simulation have major advantages in dosing regimen selection. Severe infections caused by antimicrobial-resistant strains have higher morbidity and fatality rates than other drug-susceptible infections. The author has attempted to identify the variability in efficacy and side effects using a population pharmacokinetics and pharmacodynamics analysis with anti-anti-methicillin-resistant Staphylococcus aureus (MRSA) agents. In this review presents the details of our recent research on the optimal dosing design of antimicrobial agents for the treatment of MRSA infection based on hospital pharmacometrics.

44 巻 (2021) 9 号 p. 1184
Foreword もっと読む

Peroxisome proliferator-activated receptor-α (PPARα), PPARɤ, and PPARσ/β are nuclear receptor-type transcription factors that regulate expression of multiple genes involved in metabolism. They are activated by endogenous lipids as well as synthetic ligands that include fibrate (PPARα agonists)- and glitazone (PPARɤ agonists)-class drugs. The Current Topics include single review and three original articles that argue about the PPAR–ligand physical interactions revealed by X-ray crystallography. These studies may contribute to the development of novel PPAR specific, dual, or pan agonists for therapeutics against various metabolic diseases.

44 巻 (2021) 9 号 p. 1272-1279
Viability of a Serum Infliximab Concentration-Detecting Reagent as a Qualitative Assay for an Infliximab Biosimilar もっと読む

The efficacy of infliximab in treating rheumatoid arthritis depends on its serum trough concentration. However, serum infliximab concentration-detecting reagent performance as a biosimilar remains unclear. This study aimed to investigate whether the serum infliximab concentration-detecting reagent qualitative assay yields comparable results for biosimilar infliximab and the originator product. Prepared samples were quantitatively assessed using an enzyme-linked immunosorbent assay and qualitatively using serum infliximab concentration-detecting reagent, and the results obtained for the originator and biosimilar product were compared. Serum infliximab concentration-detecting reagent yields comparable results for biosimilar infliximab and the originator product on being used as a qualitative assay for trough serum levels.

44 巻 (2021) 9 号 p. 1337-1343
Atg12-Interacting Motif Is Crucial for E2–E3 Interaction in Plant Atg8 System もっと読む

Matoba & Noda have determined the crystal structure of plant ATG12-ATG3, a complex that mediates Atg8 lipidation during autophagy, and elucidated their interaction manner. By comparison with human ATG12-ATG3 complex, the authors have identified the consensus sequence for ATG12-binding and defined it as Atg12-interacting motif (AIM12), the first identified binding motif for Atg12-family proteins.

月間アクセス数ランキング 2021年08月