EVIDENCE FOR THE PULMONARY ABSORPTION OF FLUORESCENT LABELLED MACROMOLECULAR COMPOUNDS

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To study the pulmonary absorption of macromolecular compounds, dextrans, papain, ovalbumin, serratio peptidase, human gamma globulin and catalase, fluorescein isothiocyanate (FITC) labelling of these compounds was carried out. After these FITC labelled macromolecular compounds were administered into the rat trachea, blood samples were collected from zero to 7 hr, and the serum concentration was measured. Almost all macromolecular compounds used except FITC-dextran (MW=150000) were well absorbed after their administration into the bronchia, and it has been suggested that pulmonary route is quite feasible for the administration of macromolecular compounds such as proteins, enzymes and carbohydrates to which oral route is undesirable.