Journal of Pharmacobio-Dynamics
Online ISSN : 1881-1353
Print ISSN : 0386-846X
ISSN-L : 0386-846X
IN VITRO DEMONSTRATION OF DECREASED GLUCOSE OXIDATION IN BRAIN OF EXPERIMENTALLY DIABETIC RAT AND RECOVERY BY INSULIN
IKUYO SHIMASHIGEKO KANAGUCHISADAHIKO ISHIBASHI
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Keywords: streptozotocin
JOURNAL FREE ACCESS

1979 Volume 2 Issue 2 Pages 74-77

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Abstract

In the course of studies on glucose metabolism in the brain under the condition with excessive supply of glucose, 14CO2 production from glucose-14C was examined by incubating the homogenate of the brain from control and streptozotocin-diabetic rats. The production was markedly decreased in the brain homogenate of the diabetic rats as compared with that of control rats. Administration of insulin in the diabetic rats restored the glucose oxidation activity to the control level, but about 30 min was necessary for the restoration. No difference was found between glucose-1-14C and glucose-6-14C in the change in 14CO2 production by the brain homogenate from diabetic rats before and after insulin treatment.

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© The Pharmaceutical Society of Japan
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