抄録
Direct actions of expectorants and other secretagogues on the airway system in vivo were investigated. Bronchosecretory, bronchomotor and bronchovascular responses were determined in pentobarbital-anesthetized dogs, the bronchial artery of which was perfused with blood in situ. Pilocarpine and histamine had a direct strong stimulating effect on the airway secretory cells, and potassium iodide and ammonium chloride had a mild effect, while bromhexine had almost no stimulant effect on those cells. Potassium iodide and bromhexine produced a slight bronchoconstriction. Contribution of a transvascular transudate to the respiratory tract fluid produced by expectorants or other secretagogues was suggested to be quite small.
