抄録
Male IVCS mice fed pellets containing 8 nmol methylmercuric chloride (MMC)/g feed for 32 days were additionally inhaled elemental mercury vapor (Hg°) or injected mercuric chloride (Hg2+). The modified distribution of accumulated organic mercury was observed 24 hr after exposure to inorganic mercurials. The body burden of organic mercury decreased significantly in MMC+Hg2+ treated mice and moderately (not significant) in MMC+Hg°treated mice when compared with MMC treated mice. In spite of the decreased body burden, the organic mercury levels in brain, kidneys and blood of MMC+Hg° treated mice, and in kidneys of MMC+Hg2+ treated mice were elevated. In bile, organic mercury concentration after Hg° or Hg2+ exposure was reduced. The decrease of the blood cells-to-plasma ratio of organic mercury in mice after Hg° exposure is in agreement with the data reported for workers exposed to mercury vapor.
