EFFECT OF DIISOPROPYL 1, 3-DITHIOL-2-YLIDENEMALONATE ON MICROSOMAL ELECTRON TRANSPORT SYSTEM IN RAT LIVER

Abstract

Effect of diisopropyl 1, 3-dithiol-2-ylidenemalonate (NKK-105) on the components of rat liver microsomal electron transport system was investigated by comparison with those of phenobarbital, 3-methylcholanthrene and polychlorinated biphenyl. When NKK-105 was administered to rats at a dose of 250 mg/kg/day for 7 days, cytochrome b₅ content and NADPH-cytochrome c reductase activity were significantly increased but cytochrome P-450 content to the lesser extent. Three inducers of the drug metabolizing enzymes remarkably increased cytochrome P-450 content but increased cytochrome b₅ content to a lesser extent.