Journal of Pharmacobio-Dynamics
Online ISSN : 1881-1353
Print ISSN : 0386-846X
ISSN-L : 0386-846X
PREPARATION AND ANTIGENIC PROPERTIES OF DEHYDROEPI-ANDROSTERONE SULFATE-BOVINE SERUM ALBUMIN CONJUGATES HAVING A LINKAGE THROUGH THE POSITION IN RING D
TOSHIO NAMBARAKAZUTAKE SHIMADAMITSUTERU NUMAZAWAHIROKO OHTAYOSHIKO SAWADA
著者情報
キーワード: cross-reaction
ジャーナル フリー

1980 年 3 巻 8 号 p. 407-412

詳細
抄録
The preparation and antigenic properties of two different types of dehydroepiandrosterone sulfate-bovine serum albumin (BSA) conjugates in which the hapten is linked to the carrier protein through the C-17 or C-15 position have been described. Antibodies raised against these antigens in rabbits possessed the high affinity (Ka=1.43×109-2.20×109M-1) to dehydroepiandrosterone sulfate. Antiserum elicited by immunization with the hapten-15β-BSA conjugate was specific to dehydroepiandrosterone sulfate, exhibiting no significant cross-reactivities for other sulfated steroids and no cross-reactions for free steroids and their glucuronides with an exception of 16α-hydroxydehydroepiandrosterone 3-sulfate (16.8%).
著者関連情報
© The Pharmaceutical Society of Japan
前の記事 次の記事
feedback
Top