CHARACTERISTIC BIOTRANSFORMATION OF AMINOPYRINE IN RAT WHEN ADMINISTERED WITH BARBITAL

KENJI MATSUYAMA; KAZUTAKE KADO; MASANORI NISHIUCHI; TSUYOSHI GOROMARU; OSAMI TSUZUKI; ATSUKO NODA; SADAO IGUCHI

doi:10.1248/bpb1978.4.28

KENJI MATSUYAMA, KAZUTAKE KADO, MASANORI NISHIUCHI, TSUYOSHI GOROMARU, OSAMI TSUZUKI, ATSUKO NODA, SADAO IGUCHI

著者情報

キーワード: GC-MS analyses

ジャーナルフリー

1981 年 4 巻 1 号 p. 28-34

DOI https://doi.org/10.1248/bpb1978.4.28

詳細

抄録

After the administration of aminopyrine with or without barbital to rats, aminopyrine and its main metabolites were detected in plasma and the brain by means of gas chromatography-mass spectrometry. It was clarified that a marked increase of 4-monomethylaminoantipyrine was observed in the case of coadministration of aminopyrine and barbital, while the plasma level of aminopyrine decreased significantly compared with single administration.

責任著者(Corresponding author)

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