METABOLISM OF ISONIAZID AND FREE HYDRAZINE FORMATION IN ISOLATED RAT HEPATOCYTES

MASAHARU HIRATA; YOSHINORI ASO; KUANGYANG HSU; TETSURO TABATA; KENJI MATSUYAMA; ATSUKO NODA; SADAO IGUCHI

doi:10.1248/bpb1978.4.145

MASAHARU HIRATA, YOSHINORI ASO, KUANGYANG HSU, TETSURO TABATA, KENJI MATSUYAMA, ATSUKO NODA, SADAO IGUCHI

著者情報

キーワード: mass fragmentography

ジャーナルフリー

1981 年 4 巻 2 号 p. 145-147

DOI https://doi.org/10.1248/bpb1978.4.145

詳細

抄録

Isoniazid (INH) was incubated with isolated rat hepatocytes, and the amounts of acetyl-INH, monoacetylhydrazine, diacetylhydrazine and hydrazine formed were determined by gas chromatography-mass spectrometry (GC-MS). Subsequent analyses of kinetic parameters of metabolic pathways and enzymological study of rat liver homogenate revealed that hydrazine was formed preferentially from INH, catalized by soluble hydrolytic enzymes.

責任著者(Corresponding author)

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