GLUCOSE TOLERANCE CURVES IN GENETICALLY DIABETIC KKCA^y MICE : THE PHARMACOKINETIC ANALYSIS FOR HUMPING EFFECT

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Pharmacokinetic analysis on glucose tolerance curves in genetically diabetic KK-CA^y mice treated with hypoglycemics was investigated using an analog computer. The glucose tolerance curves in KK-CA^y mice showed humping phenomena. They could not be simulated by a simple compartmental model, but might be fitted to the model containing the non-linear function."Compartment-H" model was contrived by adding the H-factor between glucose and insulin compartments. All the glucose tolerance curves in the KK-CA^y mice could be simulated reasonably by this model and some suggestions on the humping effect were obtained from the analysis of H-factor. The H-factor was observed to be influenced by adrenergic α-blocker. This pharmacokinetic approach was indicated to be useful for the pharmacological research.