DOPAMINE AND ITS ANTAGONISTS ON MOLLUSCAN SMOOTH MUSCLE

抄録

Dopamine relaxed catch contraction of an isolated molluscan smooth muscle (anterior byssus muscle of Mytilus edulis). A dose response curve of dopamine was shifted in a parallel fashion by a dopamine antagonist, domperidone, suggesting a competitive antagonism. Alpha-and beta-adrenoceptor blockers did not influence the response to dopamine. The potency order of dopamine antagonists used in this muscle was similat to that in the mammalian tissues.