ENHANCED BIOAVAILABILITY OF DIGOXIN BY γ-CYCLODEXTRIN COMPLEXATION
キーワード:
oral administration to dogs
1981 年 4 巻 9 号 p. 735-737
詳細
1981 年 4 巻 9 号 p. 735-737
Inclusion complex of digoxin with γ-cyclodextrin (γ-CyD) in 1 : 4 molar ratio was prepared, and its dissolution and absorption behaviors were compared with those of digoxin alone. The dissolution rate of digoxin in water was found to be markedly in creased by γ-CyD complexation. Bioavailability of digoxin following the oral administration of γ-CyD complex to dogs was 5.4 times as much as that of digoxin alone. The present data did indicate the improvement of dissolution and absorption characteristics of digoxin by inclusion complexation, suggesting the decrease in dose in oral digoxin therapy.
