Journal of Pharmacobio-Dynamics
Online ISSN : 1881-1353
Print ISSN : 0386-846X
ISSN-L : 0386-846X
INHIBITION BY PROPRANOLOL OF HIGH POTASSIUM-INDUCED CONTRACTIONS IN THE RAT VAS DEFERENS
NAGAO SUZUKIOSAMU INAGAKICHIHIRO TAKAYAMAYUTAKA KASUYA
著者情報
キーワード: rat vas deferens
ジャーナル フリー

1982 年 5 巻 11 号 p. 936-940

詳細
抄録
High concentrations of propranolol (10-5-3×10-4M) inhibited in a dosedependent fashion and reversibly the maximal contractile responses produced by 150 mM K+ in the rat vas deferens. 10-4M propranolol and quinine produced similar inhibitory effects on the dose-response curves to K+. Since norepinephrine-induced contractions were not substantially inhibited by quinine or propranolol, it was suggested that the two drugs may specifically inhibit the potassium-induced inflow of external calcium.
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© The Pharmaceutical Society of Japan
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