USE OF PKM-MULTI PROGRAM FOR FITTING DISCONTINUOUS ABSORPTION PROFILES USING A MICROCOMPUTER

抄録

The programs for the pharmacokinetic models with discontinuous absorption, written in BASIC, were connected to MULTI, which had been proposed for nonlinear least squares for a microcomputer by Yamaoka et al. Using this program (designated as PKMMULTI), the same data sets previously calculated by HFCM, FITISI2and NONLIN were fitted and the finally obtained estimates were in close agreement with those obtained previously. The plasma data of nalidixic acid were also fitted to the pharmacokinetic model with discontinuous absouption, which were suggested to be more valid compared with one compartment model with continuous absorption.