STRUCTURE-ACTIVITY RELATIONSHIP OF THIRTY-NINE CYTOCHALASANS OBSERVED IN THE EFFECTS ON CELLULAR STRUCTURES AND CELLULAR EVENTS AND ON ACTIN POLYMERIZATION IN VITRO

Abstract

The effects of twenty-three natural cytochalasans and sixteen synthetic derivatives on actin-distribution and alteration in morphology of C3H-2K cells, inhibition of lymphocyte capping, and inhibition of actin filament elongation were compared. The effects on cellular level and the in vitro effects showed positive correlation and the structure-activity relationship observed is discussed.