Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Improved Flow Injection Analysis (FIA) Method for Determining Selenium in Biological Samples, and the Effect of Captopril Administration on Selenium Levels and Glutathione Peroxidase Activity in Rat
Nobuyuki SUZUKIEriko FUJITAHiroyuki YASUIEiji AOYAMAHisashi TANAKATerumichi NAKAGAWA
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1993 Volume 16 Issue 11 Pages 1069-1072

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Abstract

An improved flow injection analysis (FIA) method has been developed for the determination of trace selenium in biological samples, and this method has been applied to investigate the effect of captopril, an antihypertensive drug having a thiol group, on selenium concentrations in the rat blood, liver and urine. After oral administration of captopril, selenium levels in the blood decreased, while those in the liver increased significantly. However, no pronounced effect was observed on the urinary excretion rate. The glutathione peroxidase activities in the blood and the liver were comparable to the changes in the selenium levels.

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© The Pharmaceutical Society of Japan
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