Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
CARDIAC GLYCOSIDE-INDUCED ELEVATION OF INTRACELLULAR Na+ ION CONCENTRATION IN HUMAN ERYTHROCYTES STUDIED BY 23Na NMR SPECTROSCOPY : RELATIONSHIP BETWEEN INOTROPY SPEED AND ELEVATION RATE OF INTRACELLULAR Na+ ION CONCENTRATION
Takahiro TANASENobutoshi MURAKAMIAkito NAGATSUJinsaku SAKAKIBARA
Author information
JOURNALS FREE ACCESS

1993 Volume 16 Issue 4 Pages 431-433

Details
Abstract

Elevation of intracellular sodium ion concentration in human erythrocyte induced by the cardiac glycoside, proscillaridin (1), and its four derivatives (2-5) was measured using 23Na NMR spectrometry. In this examination, there was a significant correlation between the time to half maximum inotropic effect and the time to maximum of Na+ concentrations in human erythrocyte, determined by 23Na NMR.

Information related to the author
© The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top