Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Characterization of an Acidic Polysaccharide Having Immunological Activities from the Tuber of Alisma orientale
Masashi TOMODARyoko GONDANoriko SHIMIZUNaoko OHARA
Author information
JOURNAL FREE ACCESS

1994 Volume 17 Issue 5 Pages 572-576

Details
Abstract

An acidic polysaccharide, called alisman PII, was isolated from the tuber of Alisma orientale JUZEPCZ. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 5.25×104. It is composed of L-arabinose : D-galactose : D-glucuronic acid in the molar ratio of 4 : 9 : 2, in addition to some of O-acetyl groups. Reduction of carboxyl groups, methylation analysis, nuclear magnetic resonance and controlled Smith degradation indicated that the core structural features include a backbone chain composed of β-1, 3-linked D-galactose units. Some of the galactose units in the backbone carry β-D-galactosyl side chains at position 6. Both α-1, 5-linked L-arabinosyl side chains and terminal β-D-glucuronic acid residues are linked to the core galactan units. Alisman PII showed significant potentiation of the reticuloendothelial system using a carbon clearance test and also potent anti-complementary activity.

Content from these authors
© The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top