Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Anti-inflammatory Constituents of Topically Applied Crude Drugs. V. Constituents and Anti-inflammatory Effect of Aoki, Aucuba japonica THUNB.
Mineo SHIMIZUTakashi TOMOO
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1994 Volume 17 Issue 5 Pages 665-667

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Abstract

The Et2O-soluble fraction of the MeOH extract of the leaves of Aucuba japonica THUNB. showed an anti-inflammatory effect when topically applied to rats. E-Phytol, phytone, bis (2-ethylhexyl) phthalate and friedelin were isolated as active anti-inflammatory components inhibiting carrageenin-induced paw edema. The most effective, E-phytol, inhibited histamine-induced paw edema more potently than the compound 48/80-induced edema, suggesting that the mechanism of action is due to inhibition of the H1 receptor.

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© The Pharmaceutical Society of Japan
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