1994 Volume 17 Issue 5 Pages 665-667
The Et2O-soluble fraction of the MeOH extract of the leaves of Aucuba japonica THUNB. showed an anti-inflammatory effect when topically applied to rats. E-Phytol, phytone, bis (2-ethylhexyl) phthalate and friedelin were isolated as active anti-inflammatory components inhibiting carrageenin-induced paw edema. The most effective, E-phytol, inhibited histamine-induced paw edema more potently than the compound 48/80-induced edema, suggesting that the mechanism of action is due to inhibition of the H1 receptor.