1995 Volume 18 Issue 5 Pages 785-787
The hypoglycemic effect of the rhizomes of Ophiopogonis Tuber (Liliaceae) was investigated in normal and streptozotocin-induced diabetic mice. The n-butanol extract of rhizomes of Ophiopogonis Tuber (BM) (100 mg/kg) reduced the blood glucose of normal mice from 201±13 to 151±7mg/100ml 4h after intraperitoneal administration (p<0.05), and also significantly lowered the blood glucose of streptozotocin-induced diabetic mice from 590±28 to 470±37mg/100ml under similar conditions (p<0.05). BM also tended to suppress epinephrine-induced hyperglycemia in mice. We concluded that the hypoglycemic effect of BM does not alter the insulin concentration.
