Determination of Hemoglobin A1C in Normal and Diabetic Mice : Neonatal Streptozotocin-Induced Diabetic Mice and KK-Ay Mice

Naoki KITAZAWA; Toshihiro MIURA; Mami KAKO; Masaru USAMI; Keiichiro TANIGAWA; Hitoshi ISHIDA; Yutaka SEINO

doi:10.1248/bpb.19.1078

Determination of Hemoglobin A_1C in Normal and Diabetic Mice : Neonatal Streptozotocin-Induced Diabetic Mice and KK-Ay Mice

Naoki KITAZAWA, Toshihiro MIURA, Mami KAKO, Masaru USAMI, Keiichiro TANIGAWA, Hitoshi ISHIDA, Yutaka SEINO

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Keywords: hemoglobin A_1C, NSZ, KK-Ay, blood glucose, diabetes

JOURNAL FREE ACCESS

1996 Volume 19 Issue 8 Pages 1078-1079

DOI https://doi.org/10.1248/bpb.19.1078

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Abstract

We have determined Hemoglobin A_1C (HbA_1C) in normal, neonatal streptozotocin-induced diabetic animals (NSZ), a model of lean-type non-insulin-dependent diabetes mellitus (NIDDM) with hypoinsulinaemia, and KK-Ay mice, a model of obese-type NIDDM with hyperinsulinaemia. The HbA_1C of NSZ mice was slightly increased from 5 to 20 weeks while the HbA_1C of KK-Ay mice was markedly increased from 5 to 10 weeks. Our findings showed a difference between experimentally-induced (NSZ) and genetically (KK-Ay) diabetic animals.

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