Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Inhibition of the Metallo-β-lactamase Produced from Serratia marcescens by Thiol Compounds
Masafumi GOTOTatsuya TAKAHASHIFumiko YAMASHITAAko KOREEDAHiromasa MORIMichio OHTAYoshichika ARAKAWA
Author information
JOURNALS FREE ACCESS

1997 Volume 20 Issue 11 Pages 1136-1140

Details
Abstract

Low molecular weight thiol compounds have been found to be strong inhibitors of metallo-β-lactamase (IMP-1) produced by Serratia marcescens TN9106, which was expressed by Echerichia coli JM109 cells. Mercaptoacetic acid and 2-mercaptopropionic acid strongly and competitively inhibited IMP-1 with Ki of 0.23 and 0.19 μM, respectively. 2-Mercaptoethanol reversibly inhibited IMP-1 but did not show simple competitive inhibition.

Information related to the author
© The Pharmaceutical Society of Japan
Previous article Next article
feedback
Top