Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
Pharmacological Properties of Traditional Medicines. XXIII. Searching for Active Compounds in the Blood and Bile of Rats after Oral Administrations of Extracts of Sansohnin( ?? ?? ?? )
Keiko KAWASHIMAKen-ichi SAITOAkiyoshi YAMADAShin-ichi OBARATakashi OZAKIYoshihiro KANO
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1997 Volume 20 Issue 11 Pages 1171-1174

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Abstract

We made a trial of searching for the bioactive substances from Sandohnin( ?? ?? ?? ). The blood and bile of rats after the oral administration of extracts of Sansohnin were analyzed by three-dimensional high-performance liquid chromatography (3D-HPLC). In blood, spinosin and feruloyl spinosin were found after the oral administration of a butanol extract of Sansohnin. In bile, spinosin and feruloyl spinosin were also identified after the oral administration of a water extract of Sansohnin. Spinosin and feruloyl spinosin induced the prolongation of hexobarbital sleeping time in mice at doses of 50 and 100 mg/kg, respectively. We concluded that spinosin and feruloyl spinosin were the bioactive constituents of Sansohnin. It was assumed that spinosin and feruloyl spinosin circulated through the intestine and liver, therefore, these results will provide support for the sedative and hypnotic use of this crude drug in Oriental medicine.

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© The Pharmaceutical Society of Japan
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